A comparison of the effects of two analgesic regimens on the development of persistent post-surgical pain (PPSP) after breast surgery

医学 止痛药 普瑞巴林 对乙酰氨基酚 养生 围手术期 麻醉 双氯芬酸 外科
作者
P. Lee,Niamh McAuliffe,C. I. Dunlop,M. Palanisamy,George Shorten
摘要

Background: Multimodal perioperative analgesic regimens may decrease the incidence of persistent post-surgical pain (PPSP) following surgery for breast cancer. We carried out a prospective, randomised, controlled, single-blind trial to test the hypothesis that multimodal analgesic regimen of pregabalin, paravertebral block and regular analgesics decreases the prevalence of PPSP compared to ‘standard’ analgesic regimen. Our secondary hypothesis was that associations exist between PPSP and genetic, neurophysiological, psychological and clinical parameters measured perioperatively. Methods: Fifty-one patients undergoing breast surgery were randomly allocated to either the control group, receiving ‘as required’ oral analgesics and intravenous morphine, or the intervention group, receiving a multimodal analgesic regimen consisting of perioperative pregabalin, paravertebral block and regular acetaminophen and diclofenac sodium. Clinical measurements included visual analogue scale for pain, area of hyperalgesia surrounding the surgical wound and pain catastrophising. Patients were interviewed three months postoperatively to determine the presence of persistent pain. Results: Twenty patients (20/51; 39.2%) developed PPSP. There was no difference in the incidence of PPSP between patients in the control and intervention groups (11/26; 42.3% vs 9/25; 36.0%, p = 0.39). Patients who developed PPSP and those who did not were similar in terms of perioperative clinical measurements. Conclusions: This study confirms the high prevalence (39%) of PPSP after surgery for breast cancer. The most important finding of this study is the failure to identify a benefit of a multimodal analgesic regimen consisting of perioperative pregabalin, paravertebral block and regular acetaminophen and diclofenac sodium in decreasing the incidence of PPSP three months after breast surgery compared to the ‘standard’ analgesic regimen described.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
sevenvictory应助StonesKing采纳,获得10
1秒前
迷路幻柏完成签到,获得积分10
2秒前
2秒前
3秒前
3秒前
sincere-辉完成签到,获得积分10
4秒前
爆米花应助静越采纳,获得10
4秒前
小赵发布了新的文献求助10
5秒前
楼松思完成签到,获得积分10
5秒前
luluyu完成签到,获得积分10
5秒前
Melt完成签到,获得积分10
5秒前
ottsannn发布了新的文献求助10
5秒前
Jerlly完成签到,获得积分0
5秒前
7秒前
耍酷的小土豆完成签到,获得积分10
8秒前
李健应助Albertxkcj采纳,获得10
8秒前
陈思雨发布了新的文献求助10
8秒前
HHR33完成签到,获得积分10
9秒前
9秒前
善学以致用应助罗小甜采纳,获得10
10秒前
亨利公爵发布了新的文献求助10
10秒前
甜美迎南发布了新的文献求助10
11秒前
11秒前
11秒前
温婉发布了新的文献求助10
12秒前
hredy完成签到,获得积分20
12秒前
星辰大海应助不安的橘子采纳,获得10
12秒前
13秒前
Jasper应助xkx采纳,获得10
13秒前
胆小无助但能吃完成签到,获得积分10
13秒前
13秒前
yznfly应助怡然的向南采纳,获得30
14秒前
15秒前
霏冉完成签到,获得积分10
15秒前
16秒前
16秒前
16秒前
16秒前
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969458
求助须知:如何正确求助?哪些是违规求助? 3514286
关于积分的说明 11173363
捐赠科研通 3249652
什么是DOI,文献DOI怎么找? 1794948
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804836