克洛丹
紧密连接
并行传输
封堵器
细胞生物学
跨膜蛋白
细胞结
细胞质
细胞骨架
肌动蛋白细胞骨架
细胞粘附
生物
化学
膜蛋白
生物物理学
细胞
磁导率
膜
生物化学
受体
作者
Alan S. Fanning,Laura L. Mitic,James M. Anderson
出处
期刊:Journal of The American Society of Nephrology
日期:1999-06-01
卷期号:10 (6): 1337-1345
被引量:296
摘要
Abstract. Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for regulating the paracellular permeability for water, solutes, and immune cells. Several of these proteins localize specifically within the continuous cell-to-cell contacts of the tight junction. One of these, occludin, is a cell adhesion molecule that has been demonstrated to influence ion and solute permeability. The claudins are a family of four-membrane spanning proteins; unexpectedly, other members of this family have already been characterized without recognizing their relationship to tight junctions. Junction adhesion molecule, the most recently identified tight junction component, is a member of the Ig superfamily and influences the paracellular transmigration of immune cells. A plaque of cytoplasmic proteins under the junction may be responsible for scaffolding the transmembrane proteins, creating a link to the perijunctional actin cytoskeleton and transducing regulatory signals that control the paracellular barrier.
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