First-in-Human Experience With Impella 5.0/5.5 for High-Risk Patients With Advanced Heart Failure Undergoing VT Ablation

医学 脂肪变性 高甘油三酯血症 胃肠病学 代谢综合征 内科学 脂肪肝 心力衰竭 人口 纤维化 甘油三酯 疾病 胆固醇 肥胖 环境卫生
作者
Jakub Sroubek,Ramya Vajapey,Joseph Sipko,Edward G. Soltesz,Aaron Weiss,Mandeep Bhargava,Ayman A. Hussein,Mohamed Kanj,Walid Saliba,Tyler Taigen,Oussama Wazni,Pasquale Santangeli
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:82 (5): 469-471
标识
DOI:10.1016/j.jacc.2023.05.012
摘要

Chylomicronemia syndrome is a form of severe hypertriglyceridemia (HTG) caused by the familial chylomicronemia syndrome (FCS) or multifactorial chylomicronemia syndrome (MCS). Non-alcoholic fatty liver disease (NAFLD) has been associated with components of the metabolic syndrome and is more prevalent in subjects with elevated triglycerides.The primary objective was to compare the prevalence of hepatic steatosis assessed by conventional imaging between HTG groups (FSC, MCS and moderate HTG (mHTG)). The secondary objective was to determine the difference in the prevalence of liver fibrosis.This cross-sectional observational study was performed on adult patients from the lipid clinic of the Montreal Clinical Research Institute (IRCM). We retrospectively reviewed the imaging reports available in the patients’ files for signs of NAFLD. We also used the FIB-4 index as a surrogate marker of liver fibrosis.We reviewed the medical file of 300 patients; 22 with FCS, 82 with MCS and 196 with mHTG. There was significantly more hepatic steatosis in the MCS group compared to the mHTG and FCS groups (79%, 66% and 43% respectively p=0.02). There was a significantly higher prevalence of subjects within the “unlikely fibrosis” category in the mHTG group (91%) compared to the MCS (84%) and FCS group (59%), p=0.0004.We found that the prevalence of hepatic steatosis was 3-, 2.5-, and 2-fold higher in MCS, mHTG and FCS patients than in the general population. This suggests that patients with elevated triglycerides, regardless of the underlying etiology, are at higher risk of hepatic steatosis and NAFLD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
明朗完成签到,获得积分10
刚刚
Keyl发布了新的文献求助10
1秒前
张甜完成签到,获得积分10
1秒前
YamDaamCaa应助闲听松风眠采纳,获得30
2秒前
狂野世立发布了新的文献求助10
2秒前
3秒前
陈什么烨发布了新的文献求助10
4秒前
4秒前
5秒前
情怀应助嘉嘉琦采纳,获得10
5秒前
Ava应助WSGQT采纳,获得10
6秒前
Jiang发布了新的文献求助10
7秒前
超帅听枫完成签到,获得积分20
7秒前
SYLH应助poli采纳,获得10
8秒前
生菜完成签到,获得积分10
8秒前
bxxxxx应助FFF采纳,获得30
8秒前
senhoo完成签到,获得积分10
9秒前
9秒前
JamesPei应助Ana采纳,获得10
9秒前
superbada发布了新的文献求助30
9秒前
希望天下0贩的0应助雪碧采纳,获得10
12秒前
爆米花应助科研通管家采纳,获得10
13秒前
坦率的匪应助科研通管家采纳,获得10
13秒前
13秒前
隐形曼青应助科研通管家采纳,获得10
13秒前
pcr163应助科研通管家采纳,获得80
13秒前
大模型应助科研通管家采纳,获得30
13秒前
Jasper应助科研通管家采纳,获得10
13秒前
大个应助科研通管家采纳,获得10
13秒前
科研通AI5应助舒服的乐曲采纳,获得10
13秒前
传奇3应助科研通管家采纳,获得10
13秒前
坦率的匪应助科研通管家采纳,获得10
13秒前
汉堡包应助科研通管家采纳,获得10
13秒前
13秒前
坦率的匪应助科研通管家采纳,获得10
13秒前
13秒前
quhayley应助科研通管家采纳,获得10
13秒前
要减肥岩应助科研通管家采纳,获得10
14秒前
彭于彦祖应助培爷采纳,获得30
14秒前
Mininine完成签到,获得积分10
14秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021