Dry eye disease (DED) is a complex condition characterized by the loss of tear film homeostasis, resulting in ocular symptoms, inflammation, and damage. Managing DED involves a diverse range of therapies aimed at alleviating symptoms and addressing underlying causes. This review provides a comprehensive update on current DED treatments, focusing on medications approved by the United States (US) Food and Drug Administration and notable treatments available outside the United States. Differences in treatment approaches between Asian and Western countries have been explored, highlighting the need for a nuanced understanding of regional variations. The Asia Dry Eye Society offers a new perspective on dry eye, further elucidating these regional distinctions. This review emphasizes the importance of staying informed about evolving treatment guidelines and advancements in DED therapeutics. As the field progresses with new and innovative therapies, there is increased potential for improved patient management and enhanced quality of life for individuals affected by DED.