Endocrine-Disrupting Chemicals and Disease Endpoints

内分泌系统 疾病 内分泌干扰物 内分泌疾病 生物 激素 生理学 医学 内分泌学 内科学
作者
Changhwan Ahn,Eui‐Bae Jeung
出处
期刊:International Journal of Molecular Sciences [MDPI AG]
卷期号:24 (6): 5342-5342 被引量:60
标识
DOI:10.3390/ijms24065342
摘要

Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and have been shown to interfere with physiological systems, especially by disrupting the hormone balance. During the last few decades, EDCs have been shown to affect reproductive, neurological, and metabolic development and function and even stimulate tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals have endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates. These compounds have gradually been elucidated as risk factors for many diseases, such as reproductive, neural, and metabolic diseases and cancers. Endocrine disruption has been spread to wildlife and species that are connected to the food chains. Dietary uptake represents an important source of EDC exposure. Although EDCs represent a significant public health concern, the relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and the disease endpoints associated with endocrine disruption for a better understanding of the relationship between EDCs-disease and elucidates the development of new prevention/treatment opportunities and screening methods.
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