平方毫米
胶质瘤
细胞周期
癌症研究
化学
细胞生物学
细胞生长
生物
细胞
细胞凋亡
生物化学
作者
Lili Guo,Wenjin Chen,Jiong Yue,Mingyan Gao,Jin Zhang,Yukai Huang,Huan Xiong,Xinda Li,Yangyang Wang,Ying Yuan,Longyi Chen,Fei Fan,Ruxiang Xu
标识
DOI:10.1016/j.bbadis.2024.167509
摘要
The recurrence of glioma after treatment has remained an intractable problem for many years. Recently, numerous studies have explored the pivotal role of the mouse double minute 2 (MDM2)/p53 pathway in cancer treatment. Lysine phosphate phosphohistidine inorganic pyrophosphate phosphatase (LHPP), a newly discovered tumor suppressor, has been confirmed in numerous studies on tumors, but its role in glioma remains poorly understood. Expression matrices in The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases were analyzed using gene set enrichment analysis (GSEA), revealing significant alterations in the p53 pathway among glioma patients with high LHPP expression. The overexpression of LHPP in glioma cells resulted in a reduction in cell proliferation, migration, and invasive ability, as well as an increase in apoptosis and alterations to the cell cycle. The present study has identified a novel inhibitory mechanism of LHPP against glioma, both in vivo and in vitro. The results demonstrate that LHPP exerts anti-glioma effects via the MDM2/p53 pathway. These findings may offer a new perspective for the treatment of glioma in the clinic.
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