Metabolomic biomarkers of multiple myeloma: A systematiс review

多发性骨髓瘤 奇纳 科克伦图书馆 梅德林 生物标志物 医学 肿瘤科 荟萃分析 内科学 生物 生物信息学 心理干预 生物化学 精神科
作者
NULL AUTHOR_ID,Natalia V. Mesonzhnik,I. S. Ilgisonis,Yu. N. Belenkov,NULL AUTHOR_ID,NULL AUTHOR_ID
出处
期刊:Biochimica Et Biophysica Acta - Reviews On Cancer [Elsevier]
卷期号:1879 (5): 189151-189151 被引量:1
标识
DOI:10.1016/j.bbcan.2024.189151
摘要

Multiple myeloma (MM) is an incurable malignancy of clonal plasma cells. Various diagnostic methods are used in parallel to accurately determine stage and severity of the disease. Identifying a biomarker or a panel of biomarkers could enhance the quality of medical care that patients receive by adopting a more personalized approach. Metabolomics utilizes high-throughput analytical platforms to examine the levels and quantities of biochemical compounds in biosamples. The aim of this review was to conduct a systematic literature search for potential metabolic biomarkers that may aid in the diagnosis and prognosis of MM. The review was conducted in accordance with PRISMA recommendations and was registered in PROSPERO. The systematic search was performed in PubMed, CINAHL, SciFinder, Scopus, The Cochrane Library and Google Scholar. Studies were limited to those involving people with clinically diagnosed MM and healthy controls as comparators. Articles had to be published in English and had no restrictions on publication date or sample type. The quality of articles was assessed according to QUADOMICS criteria. A total of 709 articles were collected during the literature search. Of these, 436 were excluded based on their abstract, with 26 more removed after a thorough review of the full text. Finally, 16 articles were deemed relevant and were subjected to further analysis of their data. A number of promising candidate biomarkers was discovered. Follow-up studies with large sample sizes are needed to determine their suitability for clinical applications.
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