双特异性抗体
抗体
核工程
核磁共振
物理
医学
工程类
免疫学
单克隆抗体
作者
Borna Roohani,Alejandra López Méndez,Mann Dangarwala,Samantha Katz,Bernadette Marquez‐Nostra
标识
DOI:10.2967/jnumed.123.267215
摘要
Bispecific antibodies (bsAbs) are engineered to target 2 different epitopes simultaneously. About 75% of the 16 clinically approved bsAbs have entered the clinic internationally since 2022. Hence, research on biomedical imaging of various radiolabeled bsAb scaffolds may serve to improve patient selection for bsAb therapy. Here, we provide a comprehensive overview of recent advances in radiolabeled bsAbs for imaging via PET or SPECT. We compare direct targeting and pretargeting approaches in preclinical and clinical studies in oncologic research. Furthermore, we show preclinical applications of imaging bsAbs in neurodegenerative diseases. Finally, we offer perspectives on the future directions of imaging bsAbs based on their challenges and opportunities.
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