Deoxyfluorination: A Detailed Overview Of Recent Developments

Fluorine organic compounds have been a predominant force of pharmaceutical chemistry for modern drug design with an increasing amount of fluorine-containing compounds entering the market. Methodologies for fluorine atom incorporation into organic molecules are still challenging to date and thus represent an important research area. Deoxyfluorination reaction serves as a useful tool for construction of carbon-fluorine bonds in biologically active molecules by converting a common hydroxyl group into corresponding fluoride. In this review we have summarized and categorized deoxyfluorination reaction protocols developed over the last decade (2015-2024) by the structural type of C-O bond deoxyfluorination including substrates like alcohols, phenols, ketones, aldehydes, and carboxylic acids. 1 Introduction 2 Deoxyfluorination of (Csp2)-O bonds 3 Deoxyfluorination of (Csp3)-O bonds 4 Conclusions