Nanomedicine‐mediated Magneto‐dynamic and/or Magneto‐thermal Therapy

Nanomedicine-mediated magnetodynamic and/or magnetothermal therapies have become the frontier topics in recent years, especially in the field of tumor treatment. Magnetic field-induced hyperthermia was to utilize nanosized magnetic particles localized in tumor tissues to be heated up to a high temperature (usually more than 39 °C) after applying an external alternating magnetic field. The mechanism is based on the magnetic hysteresis, relaxation, or induction of eddy currents in the magnetic nanoparticles or their aggregates, which can increase the temperature of the tumor tissue and then induce tumor cell apoptosis and necrosis, achieving tumor treatment. This chapter introduces the related concept, treatment theory, and operation methods of magnetic hyperthermia, mainly including the magnetic heat conversion mechanism, the killing effect of magnetic hyperthermia on tumor cells, and the cytotoxicity of nanomedicines. In addition, this chapter also summarizes some typical magnetic field-responsive nanoparticles (NPs) for the fabrication of nanomedicines and the corresponding synthesis methods such as Fe 3 O 4 NPs, iron NPs, magnetic metal alloy NPs, etc. Some typical applications will be described to elucidate their features in special disease treatment, such as improving the motor symptoms of Parkinson's model mice, and magnetic hyperthermia for the treatment of tumors and knee osteoarthritis.