呋喃
单线态氧
化学
充氧
阿卡波糖
产量(工程)
组合化学
光化学
氧气
药物化学
有机化学
材料科学
医学
内科学
酶
冶金
作者
Ram Awatar Maurya,Sanjay Kumar,Anupriya Borah,Satheesh Borra,Prasenjit Manna,Sabapathi Gokulnath,Ram Awatar Maurya
标识
DOI:10.1021/acs.joc.4c01312
摘要
Photocatalyst-free visible light-enabled direct oxygenation of furan-tethered α-azidoketones was studied. The reaction yielded various products depending on the substituents, with isoxazoles forming as the major products. The findings suggest that singlet oxygen was generated during the reaction and reacted with α-azidoketones in a [4 + 2] fashion to yield endoperoxides, which rearranged in multiple ways to generate isoxazoles. Some of the synthesized isoxazoles were evaluated as α-glucosidase inhibitors, and three of them 5bi, 5bj, and 5bl exhibited good activity with IC50 values of 454.57 ± 29.34, 147.84 ± 2.28, and 272.58 ± 42.06 μM, respectively, when compared with the standard drug acarbose (IC50 = 1224.33 ± 126.72 μM).
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