姜黄素
体内
肝星状细胞
化学
药物输送
体外
药理学
肝损伤
药品
纤维化
氧化应激
癌症研究
生物物理学
细胞生物学
生物化学
医学
生物
病理
有机化学
生物技术
作者
Yuan Kun,Keren Lai,Guifeng Miao,Jibin Zhang,Xiaoxi Zhao,Guozhu Tan,Xiaowu Wang,Xiaorui Wang
标识
DOI:10.1021/acs.biomac.4c00691
摘要
Here, we report novel cholinized-polymer functionalized lipid-based nanoparticles (CP-LNPs) for rapid and highly effective delivery of drugs to the liver, achieving targeting within 10 min and nearly 100% efficiency. In this study, CP-LNPs loaded with a promising antifibrotic agent curcumin (CP-LNPs/Cur) significantly improved the stability of curcumin under physiological conditions and its distribution in the liver. In vitro experiments demonstrated that CP-LNPs/Cur effectively suppressed the proliferation and migration of activated hepatic stellate cells (aHSCs), as evidenced by the decreased expression of α-SMA. Moreover, CP-LNPs/Cur attenuated oxidative stress levels in hepatocytes while improving mitochondrial physiological activity. In vivo antifibrosis studies have shown that CP-LNPs/Cur only require a low dose to significantly alleviate liver injury and collagen deposition, thereby preventing the progression of liver fibrosis. These findings indicated that CP-LNPs exhibit great potential in liver fibrosis therapy benefiting from the novel targeting strategy.
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