淋巴系统
创伤性脑损伤
淋巴系统
平衡
医学
神经科学
脑损伤
免疫学
病理
生物
内科学
脑脊液
精神科
作者
Shiqiang Tong,Laozhi Xie,Xiaoying Xie,Jianpei Xu,Yang You,Yinzhe Sun,Songlei Zhou,Chuchu Ma,Gan Jiang,Fenfen Ma,Zhihua Wang,Xiaoling Gao,Jun Chen
标识
DOI:10.1002/advs.202304284
摘要
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Long-term changes in the microenvironment of the brain contribute to the degeneration of neurological function following TBI. However, current research focuses primarily on short-term modulation during the early phases of TBI, not on the critical significance of long-term homeostasis in the brain microenvironment. Notably, dysfunction of the glymphatic-lymphatic system results in the accumulation of danger/damage-associated molecular patterns (DAMPs) in the brain, which is regarded as the leading cause of long-term microenvironmental disturbances following TBI. Here, a nanostructure, Nano-plumber, that co-encapsulates the microenvironment regulator pro-DHA and the lymphatic-specific growth factor VEGF-C is developed, allowing for a sustainable and orderly regulation of the microenvironment to promote long-term neurological recovery. Nano-plumber reverses the injury microenvironment by suppressing microglia and astrocytes activation and maintaining reduced activation via enhanced glymphatic-lymphatic drainage, and significantly improves the neurological function of rodents with TBI. This study demonstrates that glymphatic-lymphatic system reconstruction is essential for enhancing long-term prognosis following TBI, and that the Nano-plumber developed here may serve as a clinically translatable treatment option for TBI.
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