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Association Between Immune-Related Disease and Allergic Rhinitis: A Two-Sample Mendelian Randomization Study

医学 单核苷酸多态性 孟德尔随机化 哮喘 全基因组关联研究 免疫学 疾病 免疫系统 内科学 类风湿性关节炎 基因型 遗传学 遗传变异 基因 生物
作者
Jinming Zhao,Mengmeng Zhang,Zufei Li
出处
期刊:American Journal of Rhinology & Allergy [SAGE Publishing]
卷期号:38 (1): 31-37 被引量:6
标识
DOI:10.1177/19458924231207131
摘要

Immune-related diseases can interact with each other, and growing evidence suggests that these diseases are associated with allergic rhinitis (AR). However, it is unclear whether previously observed associations reflect causal relationships.This study estimated the genetic association between various immune-related diseases and AR using two-sample Mendelian randomization (MR).Eight immune-related diseases were selected as exposure factors, and AR was selected as the outcome. The 8 immune-related disease categories included atopic dermatitis (AD), Graves' disease (GD), asthma, Crohn's disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ulcerative colitis (UC). Data from GWAS (Genome-Wide Association Studies) were selected to construct instrumental variables (IVs) for each disease, and multiple single-nucleotide polymorphisms (SNPs) were selected as IVs. Corresponding data were retrieved according to the selected SNPs, and all data were summarized and analyzed.A total of 416 SNPs were screened as IVs, and the results of IVW support a causal relationship between AR risk and AD (OR: 1.026, 95% CI: 1.014-1.038, P = 9.59 × 10-6), asthma (OR: 1.057, 95% CI: 1.029-1.086, P = .0001), and CD (OR: 1.006, 95% CI: 1.002-1.011, P = .0085). Furthermore, GD (OR: 0.995, 95% CI: 0.991-0.999, P = .0213) and SLE (OR: 0.997, 95% CI: 0.995-1.000, P = .025) may be protective factors.This MR study found that AD, asthma and CD increase the risk of AR in populations of European ancestry, GD and SLE may be protective factors. These results suggest that confounding factors may have influenced associations previously reported in observational studies.
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