Near–infrared–excited photothermal–pyroelectric synergy promoted paper–based sensing platform for enhanced photoelectrochemical analysis performance

Exploring and regulating photothermal materials–driven pyroelectric effects may aroused remarkable possibilities for the next generation of in–vitro point–of–care diagnosis. In the pursuit of this goals, the powerful impact of near–infrared light (NIR) has been largely neglected. Herein, a concise yet energetic NIR–excited photothermal–pyroelectric sensing platform had been successfully developed for sensitive let–7a detection. To realize it, the energy harvest was firstly achieved from flexibility polyimide–paper–based electrode on photothermal–pyroelectric. Under NIR irradiation, the photothermal–active matrix of ZnO/AgBiS2 with the electronic configuration and allosteric triple–helix effector with pyroelectric SrTiO3 were switched by fluctuation of thermal–field and pyroelectric–field, facilitating the separation of NIR–responsive carriers. During the process, the effector could regulate the activity of the CRISPR–Cas12a system according to the dose of the let–7a, reasonably leading to the precise quantification of targets with the detection limits of 1.68 fM. Besides, the effect of temperature variation on the sensing platform was investigated, revealing the NIR–excited synergy between photothermal effect and pyroelectric field. This work broadens new horizons towards upgrading the overall performance of photoelectrochemical sensing platform by more efficiently.