High‐Resolution Recording of Neural Activity in Epilepsy Using Flexible Neural Probes

Abstract Epilepsy, a prevalent neurological disorder, necessitates precise and reliable electrophysiological recording for accurate study and diagnosis. Although traditional stereo‐electroencephalography and micro‐wire probes are widely used in epilepsy research, they are limited by recording site numbers and mechanical properties. This study explores the use of high‐density, ultra‐flexible neural probes in epilepsy monitoring, highlighting their advantages in terms of recording performance, scalability, and tissue compatibility. This work validates the effectiveness of the probes in detecting characteristic epileptic signals across various stages, including resting, preictal, and ictal stages, in two different mouse models of epilepsy. Additionally, the high spatial resolution of the probes allows to capture fine spatial propagation of epilepsy‐associated high‐frequency oscillations. Furthermore, the flexible probes exhibit superior biocompatibility, reducing inflammation and neuronal apoptosis compared to rigid electrodes. The results underscore the promising potential of ultra‐flexible neural probes for advancing epilepsy research, providing a powerful technological platform for future studies in the field.