Research progress of photodynamic therapy based on porphyrin-metal organic framework materials

Abstract： Porphyrin-metal-organic frameworks (MOFs) materials are a new class of porous materials composed of metal nodes and porphyrin organic ligands.The porphyrin ligands on the MOFs can exert photodynamic therapy (PDT) under light excitation.This kind of PDT material with porous structure can play the functions of drug loading and multifunctional modification in the treatment of diseases.Some MOFs with unique metal sites also have the func• tion of nanozymes.In recent years， this kind of porphyrin-MOFs has become an important research direction in the field of PDT.At present， such materials need to solve problems such as oxygen concentration and energy transfer effi• ciency before being promoted to the clinic.Researchers have also given many solutions， and adopt different methods to enhance PDT according to the different environments faced in the actual application process， including increasing oxygen concentration， improving the energy transfer process， consumption of functional molecules， generation of sig• nal molecules and synergistic strategies.This paper reviews the representative work in recent years， including por• phyrin-MOFs materials and the mechanism of PDT generation， the application and latest progress of PDT of porphy• rin-MOFs materials， finally， the future development trend of PDT for porphyrin-MOFs materials in the field of bio• medicine has prospected.