Sprayable CeCuOx Nanocatalytic Gel for Synergistic Antibacterial Therapy

The bacterial microenvironment-activated nanocatalytic antibacterial strategy has attracted extensive attention owing to the high specificity to eliminate pathogens, which provides opportunities to solve antibiotic resistance. However, the relatively high pH value and insufficient endogenous H2O2 level in bacterial microenvironment limits the efficiency of Fenton reactions induced by these nanocatalytic agents, leading to unsatisfied antibacterial performance. Herein, bimetallic peroxide was first reported as a high-efficiency antibacterial nanocatalyst with high pH-activated, H2O2 self-supply and synergistic effect-enhanced cascade Fenton chemistry. An isolated spray vial was further developed to achieve in situ gelation at the wound site, adapt to irregular wound surface, and maintain long-term release of nanocatalyst. As a result, wound healing was efficiently promoted corresponding to excellent nanocatalytic antibacterial efficacy. Thus, our in situ sprayed nanocatalytic antibacterial gel provides a promising paradigm for high-efficiency bacterial infection therapy.