Regional homogeneity alterations in patients with functional constipation and their associations with gene expression profiles

功能性便秘 便秘 壳核 眶额皮质 神经科学 医学 丘脑 扣带回前部 人脑 病理生理学 功能磁共振成像 静息状态功能磁共振成像 心理学 内科学 前额叶皮质 认知
作者
Wangli Cai,Hongliang Tian,Peiwen Sun,Hua Ting,Jian Gong,Ruiling Zhang,Lidi Wan,Guoqing Gu,Haiying Zhang,Guangyu Tang,Qiyi Chen,Zhang Li
出处
期刊:Cerebral Cortex [Oxford University Press]
被引量:1
标识
DOI:10.1093/cercor/bhad403
摘要

Abstract Functional constipation, a highly prevalent functional gastrointestinal disorder, often accompanies by mental and psychological disorders. Previous neuroimaging studies have demonstrated brain functional and structural alterations in patients with functional constipation. However, little is known about whether and how regional homogeneity is altered in these patients. Moreover, the potential genetic mechanisms associated with these alterations remain largely unknown. The study included 73 patients with functional constipation and 68 healthy controls, and regional homogeneity comparison was conducted to identify the abnormal spontaneous brain activities in patients with functional constipation. Using Allen Human Brain Atlas, we further investigated gene expression profiles associated with regional homogeneity alterations in functional constipation patients with partial least squares regression analysis applied. Compared with healthy controls, functional constipation patients demonstrated significantly decreased regional homogeneity in both bilateral caudate nucleus, putamen, anterior insula, thalamus and right middle cingulate cortex, supplementary motor area, and increased regional homogeneity in the bilateral orbitofrontal cortex. Genes related to synaptic signaling, central nervous system development, fatty acid metabolism, and immunity were spatially correlated with abnormal regional homogeneity patterns. Our findings showed significant regional homogeneity alterations in functional constipation patients, and the changes may be caused by complex polygenetic and poly-pathway mechanisms, which provides a new perspective on functional constipation’s pathophysiology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
刚刚
zxy完成签到,获得积分10
1秒前
sober完成签到,获得积分10
1秒前
1秒前
mmknnk完成签到,获得积分20
1秒前
cc2064完成签到 ,获得积分10
1秒前
调皮冰旋发布了新的文献求助10
2秒前
西哈哈完成签到,获得积分20
2秒前
2秒前
2秒前
2秒前
Orange应助幸福胡萝卜采纳,获得10
2秒前
SHDeathlock完成签到,获得积分10
3秒前
习习发布了新的文献求助100
4秒前
Jolene66完成签到,获得积分10
4秒前
研友_8RlQ2n发布了新的文献求助10
4秒前
5秒前
852应助Pangsj采纳,获得10
5秒前
Song完成签到 ,获得积分10
5秒前
5秒前
6秒前
大胆夜绿发布了新的文献求助10
6秒前
Dr终年完成签到,获得积分10
6秒前
katharsis完成签到,获得积分10
6秒前
Ricardo发布了新的文献求助10
7秒前
歪歪象发布了新的文献求助10
7秒前
zeno123456完成签到,获得积分10
7秒前
陈某某发布了新的文献求助10
7秒前
8秒前
he完成签到,获得积分10
8秒前
8秒前
科研小民工应助忍冬半夏采纳,获得30
8秒前
小马甲应助年华采纳,获得10
8秒前
8秒前
CipherSage应助开放的听枫采纳,获得10
8秒前
Never stall发布了新的文献求助10
8秒前
8秒前
Jolene66发布了新的文献求助10
9秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527469
求助须知:如何正确求助?哪些是违规求助? 3107497
关于积分的说明 9285892
捐赠科研通 2805298
什么是DOI,文献DOI怎么找? 1539865
邀请新用户注册赠送积分活动 716714
科研通“疑难数据库(出版商)”最低求助积分说明 709678