Regional homogeneity alterations in patients with functional constipation and their associations with gene expression profiles

功能性便秘 便秘 壳核 眶额皮质 神经科学 医学 丘脑 扣带回前部 人脑 病理生理学 功能磁共振成像 静息状态功能磁共振成像 心理学 内科学 前额叶皮质 认知
作者
Wangli Cai,Hongliang Tian,Peiwen Sun,Hua Ting,Jian Gong,Ruiling Zhang,Lidi Wan,Guoqing Gu,Haiying Zhang,Guangyu Tang,Qiyi Chen,Zhang Li
出处
期刊:Cerebral Cortex [Oxford University Press]
被引量:1
标识
DOI:10.1093/cercor/bhad403
摘要

Abstract Functional constipation, a highly prevalent functional gastrointestinal disorder, often accompanies by mental and psychological disorders. Previous neuroimaging studies have demonstrated brain functional and structural alterations in patients with functional constipation. However, little is known about whether and how regional homogeneity is altered in these patients. Moreover, the potential genetic mechanisms associated with these alterations remain largely unknown. The study included 73 patients with functional constipation and 68 healthy controls, and regional homogeneity comparison was conducted to identify the abnormal spontaneous brain activities in patients with functional constipation. Using Allen Human Brain Atlas, we further investigated gene expression profiles associated with regional homogeneity alterations in functional constipation patients with partial least squares regression analysis applied. Compared with healthy controls, functional constipation patients demonstrated significantly decreased regional homogeneity in both bilateral caudate nucleus, putamen, anterior insula, thalamus and right middle cingulate cortex, supplementary motor area, and increased regional homogeneity in the bilateral orbitofrontal cortex. Genes related to synaptic signaling, central nervous system development, fatty acid metabolism, and immunity were spatially correlated with abnormal regional homogeneity patterns. Our findings showed significant regional homogeneity alterations in functional constipation patients, and the changes may be caused by complex polygenetic and poly-pathway mechanisms, which provides a new perspective on functional constipation’s pathophysiology.
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