单宁酸
明胶
抗菌剂
止血
自愈水凝胶
生物相容性
材料科学
化学
纳米技术
高分子化学
生物化学
有机化学
外科
医学
作者
Chang Xu,Pan Xu,Yang Gao,Feng Gao,Xijing Zhuang,Hao Zhang,Xufeng Dong
标识
DOI:10.1016/j.coco.2023.101743
摘要
The development of ideal hemostatic materials is of great significance in accelerating wound healing and reducing patient pain. However, the current hemostatic materials mostly have a single effect, making it difficult to simultaneously address bacterial infection and exudate leakage issues during the hemostasis process. In this paper, gelatin/tannic acid/Laponite (GTL) hemostatic hydrogels with excellent mechanical and antimicrobial properties were prepared. The synergistic hierarchical cross-linking structure of Laponite and tannic acid endowed the hydrogel with satisfactory mechanical properties, including elongation at break (360%) and modulus of elasticity (10.9 kPa) comparable to that of isolated skin. Besides, the introduction of Laponite effectively controlled the release amount and rate of tannic acid, providing excellent biocompatibility of the material. Moreover, the GTL hydrogel exhibited ideal antimicrobial effect and good inhibition against both E. coli and S. aureus. Notably, this hydrogel showed an in vitro coagulation index of 15.7% and had good blood coagulation performance and excellent cell adhesion, making it promising for use as a hemostatic antimicrobial dressing.
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