Schottky Heterojunction Facilitates Osteosarcoma Ferroptosis and Enhances Bone Formation in a Switchable Mode

材料科学 异质结 肖特基势垒 骨肉瘤 光电子学 肖特基二极管 癌症研究 纳米技术 医学 二极管
作者
Zhongyang Lv,Yizhang Wu,Jintao Lin,Weitong Li,Hannah Weisbecker,Peng Wang,Xueru Song,Wei Sun,Ziying Sun,Xie Ya,Meng Jia,Jian Dong,Xueying An,Jiaqi Chen,Shaoqiang Yang,Tao Yuan,Hui Jiang,Chang Sun,Xiaojiang Yang,Hong Qian
出处
期刊:Advanced Functional Materials [Wiley]
被引量:11
标识
DOI:10.1002/adfm.202312032
摘要

Abstract Effective antitumor agents with concurrent osteogenic properties are essential for comprehensive osteosarcoma (OS) treatment. However, the current clinical therapeutic strategies of OS fail to completely eradicate tumors while simultaneously encouraging bone formation. To address this issue, a switchable strategy for dynamic OS ablation and static bone regeneration is developed by integrating piezoelectric BaTiO 3 (BTO) with atomic‐thin Ti 3 C 2 (TC) through a Schottky heterojunction, resulting in the formation of TC@BTO. Under sequential ultrasound and near‐infrared irradiation, the optimized carrier transport of TC@BTO, based on Schottky heterojunction, exhibits excellent characteristics of photothermal conversion and reactive oxygen species generation. This results in ferroptosis of tumor cells and eventual elimination of OS. Moreover, in the static state, the interfacial Schottky heterojunction facilitates the carriers’ directed transfer from the semiconductor to the metal. The Schottky heterojunction‐enhanced static electrical stimulation enhances the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells and repair of bone defects. Furthermore, RNA‐sequencing analysis reveals that static TC@BTO promotes bone regeneration by activating Wnt signaling pathway, and remarkably, pharmacological inhibition of Wnt signaling suppresses the TC@BTO‐induced osteogenesis. Overall, this work broadens the biomedical potential of Schottky heterojunction‐based therapies and provides a comprehensive strategy for overall OS ablation and bone regeneration.
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