小RNA
肺结核
生物标志物
结核分枝杆菌
鉴定(生物学)
分子诊断学
生物
计算生物学
疾病
医学
生物信息学
病理
遗传学
基因
生态学
作者
Piyush Agrawal,Aditya Upadhyay,Awanish Kumar
标识
DOI:10.1016/j.diagmicrobio.2023.116082
摘要
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a lethal infectious disease that is prevalent worldwide. During TB infection, host microRNAs change their expression in the form of up/down-regulation. The identification of unique host microRNAs during TB could serve as potential biomarkers in the early detection of TB. microRNAs fulfill the required criteria for being an ideal biomarker, such as sensitivity, high specificity, and accessibility. Therefore, the recognition of potential host microRNAs can be valuable for the diagnosis of TB. The field of miRNA biomarkers in TB requires more extensive research to identify potential biomarkers. This review provides an overview of the biogenesis and biological functions of microRNAs and presents the findings of various studies on the identification of potential biomarkers for TB. Research momentum is gaining in this field and we anticipate that miRNAs will become a routine approach in the development of reliable diagnostic and specific therapeutic interventions in future.
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