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Associations between exposure to air pollution and sex hormones during the menopausal transition

四分位间距 更年期 激素 促卵泡激素 生理学 医学 内分泌学 内科学 促黄体激素
作者
Xin Wang,Ning Ding,Sioḃán D. Harlow,John F. Randolph,Ellen B. Gold,Carol A. Derby,Howard M. Kravitz,Gail A. Greendale,Xiangmei Wu,Keita Ebisu,Joel Schwartz,Sung Kyun Park
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:908: 168317-168317 被引量:5
标识
DOI:10.1016/j.scitotenv.2023.168317
摘要

Menopause is a significant milestone in a woman's life, characterized by decreasing estradiol (E2) and increasing follicle-stimulating hormone (FSH) levels. Growing evidence suggests that air pollution may affect reproductive health and disrupt hormone profiles, yet the associations in women undergoing menopausal transition (MT) remains underexplored. We examined the associations between annual air pollutant exposures and repeated measures of E2 and FSH in 1365 women with known final menstrual period (FMP) date from the Study of Women's Health Across the Nation. Air pollution was calculated as the annual averages of 24-h average PM2.5 levels, daily one-hour maximum NO2 levels, and daily 8-h maximum O3 levels. Linear mixed models with piece-wise linear splines were used to model non-linear trajectories of E2 and FSH in three distinct time periods: up to 2 years before the FMP (early MT), within 2 years before and 2 years after FMP (transmenopause), and >2 years post-FMP (postmenopause). In the transmenopausal period, an interquartile (5 μg/m3) increase in PM2.5 was associated with a significant decrease in E2 levels (−15.7 %, 95 % CI: −23.7, −6.8), and a 10 ppb increase in NO2 was associated with a significant decrease in E2 levels (−9.2 %, 95 % CI: −16.2, −1.7). A higher PM2.5 was also associated with an accelerated rate of decline in E2. Regarding FSH, a 10 ppb increase in NO2 was associated with decline in FSH levels (−11.7 %, 95 % CI: −21.8, −0.1) in the early MT and accelerated rates of decline in the postmenopause (−1.1 % per year, 95 % CI: −2.1, −0.1). Additionally, inverse associations between O3 and FSH were observed in the transmenopause and postmenopause. Our study suggests that increases in PM2.5, NO2, and O3 exposures are linked to significant declines in E2 and FSH levels across menopausal stages, suggesting the detrimental impact of air pollutants on women's reproductive hormones.
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