[Advances in the applications of dissolving polymer microneedles for delivering drugs in ocular diseases].

Due to the unique anatomical structure and physiological barriers of the eye, drug delivery for ocular diseases presents a formidable challenge. Conventional methods of ocular drug administration often suffer from limitations such as low drug bioavailability and a lack of tissue targeting, necessitating multiple administrations to achieve the desired therapeutic drug concentrations. In recent years, microneedles, known for their attributes of safety, minimally invasive application, and high efficiency, have found widespread application in ocular drug delivery research. Among the various types of microneedles, dissolving polymer microneedles have emerged as a prominent focus in the field of ocular drug delivery due to their distinct advantages over other microneedle types. This article provides a comprehensive summary and outlook on the progress in the application of dissolving polymer microneedles for drug delivery in ocular diseases.由于眼球特殊解剖结构和生理屏障的限制，眼部疾病的药物递送极具挑战。眼部药物的传统给药方式普遍存在药物生物利用度低、缺乏组织靶向性等不足，需多次给药以达到理想的药物治疗浓度。由于具备安全、微创、高效等特点，微针近年来已被广泛应用于眼部药物递送的研究。而可溶性聚合物微针作为微针中的一大类，因其相较于其他类型微针的独特优势已成为眼部给药领域研究热点。基于此，本文对可溶性聚合物微针在眼部疾病药物递送中的应用研究进展进行总结和展望。.