材料科学
超声波
图层(电子)
药物输送
联轴节(管道)
纳米技术
复合材料
医学
放射科
作者
Xiaoyu Han,Fan Wang,Jieliang Shen,Shuyu Chen,Pengcheng Xiao,Ying Zhu,Weiwei Yi,Zhengyu Zhao,Zhengwei Cai,Wenguo Cui,Dingqun Bai
标识
DOI:10.1002/adma.202306993
摘要
Abstract Conventional coupling agents (such as polyvinylpyrrolidone, methylcellulose, and polyurethane) are unable to efficiently transport drugs through the skin's dual barriers (the epidermal cuticle barrier and the basement membrane barrier between the epidermis and dermis) when exposed to ultrasound, hindering deep and noninvasive transdermal drug delivery. In this study, nanobubbles prepared by the double emulsification method and aminated hyaluronic acid are crosslinked with aldehyde‐based hyaluronic acid by dynamic covalent bonding through the Schiff base reaction to produce an innovative ultrasound‐nanobubble coupling agent. By amplifying the cavitation effect of ultrasound, drugs can be efficiently transferred through the double barrier of the skin and delivered to deep layers. In an in vitro model of isolated porcine skin, this agent achieves an effective penetration depth of 728 µm with the parameters of ultrasound set at 2 W, 650 kHz, and 50% duty cycle for 20 min. Consequently, drugs can be efficiently delivered to deeper layers noninvasively. In summary, this ultrasound nanobubble coupling agent efficiently achieves deep‐layer drug delivery by amplifying the ultrasonic cavitation effect and penetrating the double barriers, heralding a new era for noninvasive drug delivery platforms and disease treatment.
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