What a Single Electroencephalographic (EEG) Channel Can Tell us About Alzheimer's Disease Patients With Mild Cognitive Impairment

头皮 脑电图 痴呆 接收机工作特性 听力学 快速傅里叶变换 医学 光谱密度 认知障碍 阿尔法(金融) 心理学 内科学 疾病 心脏病学 神经科学 计算机科学 外科 临床心理学 电信 算法 心理测量学 结构效度
作者
Claudio Del Percio,Susanna Lopez,Giuseppe Noce,Roberta Lizio,Federico Tucci,Andrea Soricelli,Raffaele Ferri,Flavio Nobili,Dario Arnaldi,Francesco Famà,Carla Buttinelli,Franco Giubilei,Moira Marizzoni,Bahar Güntekin,Görsev Yener,Fabrizio Stocchi,Laura Vacca,Giovanni B. Frisoni,Claudio Babiloni
出处
期刊:Clinical Eeg and Neuroscience [SAGE Publishing]
卷期号:54 (1): 21-35 被引量:8
标识
DOI:10.1177/15500594221125033
摘要

Abnormalities in cortical sources of resting-state eyes closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10-20 montage) with 19 scalp electrodes characterized Alzheimer's disease (AD) from preclinical to dementia stages. An intriguing rsEEG application is the monitoring and evaluation of AD progression in large populations with few electrodes in low-cost devices. Here we evaluated whether the above-mentioned abnormalities can be observed from fewer scalp electrodes in patients with mild cognitive impairment due to AD (ADMCI). Clinical and rsEEG data acquired in hospital settings (10-20 montage) from 75 ADMCI participants and 70 age-, education-, and sex-matched normal elderly controls (Nold) were available in an Italian-Turkish archive (PDWAVES Consortium; www.pdwaves.eu). Standard spectral fast fourier transform (FFT) analysis of rsEEG data for individual delta, theta, and alpha frequency bands was computed from 6 monopolar scalp electrodes to derive bipolar C3-P3, C4-P4, P3-O1, and P4-O2 markers. The ADMCI group showed increased delta and decreased alpha power density at the C3-P3, C4-P4, P3-O1, and P4-O2 bipolar channels compared to the Nold group. Increased theta power density for ADMCI patients was observed only at the C3-P3 bipolar channel. Best classification accuracy between the ADMCI and Nold individuals reached 81% (area under the receiver operating characteristic curve) using Alpha2/Theta power density computed at the C3-P3 bipolar channel. Standard rsEEG power density computed from six posterior bipolar channels characterized ADMCI status. These results may pave the way toward diffuse clinical applications in health monitoring of dementia using low-cost EEG systems with a strict number of electrodes in lower- and middle-income countries.
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