DNA甲基化
甲基化
甲基转移酶
维生素
炎症
DNA损伤
维生素D与神经学
B族维生素
化学
同型半胱氨酸
DNA
内科学
内分泌学
医学
药理学
免疫学
生物化学
基因
基因表达
作者
Jun Bai,Lanlan Tang,Yang Luo,Zhixia Han,Chenwen Li,Yaochuan Sun,Qi Sun,Junhao Lu,Hao Qiu,Zuohui Zhao,Tingting Huo,Wei Xiong,Qingbi Zhang
摘要
This study aimed to explore whether vitamin B complex (folic acid, B6 , and B12 ) could avert DNA methylation changes associated with inflammation induced by acute PM2.5 exposure. Sprague-Dawley rats were administered by gavage with different concentrations of vitamin B complex once a day for 28 days, and then by intratracheal instillation with saline or PM2.5 once every 2 days for three times. Vitamin B continued to be taken during the PM2.5 exposure. Rats were sacrificed 24 h after the last exposure. The results showed that vitamin B complex could block the pathological changes and injury in lungs induced by PM2.5 . Meanwhile, vitamin B complex could prevent the abnormal DNA methylation of IL-4 and IFN-γ to antagonize the imbalance of IL-4/IFN-γ associated with inflammation. It was further found that vitamin B complex could regulate DNA methyltransferases (DNMTs) and increase the S-adenosylmethionine (SAM)/S-Adenosyl-L-homocysteine (SAH) ratio to reverse the hypomethylation of genomic DNA and the abnormal DNA methylation of IL-4 and IFN-γ. In conclusion, vitamin B complex has a protective effect on acute lung injury by attenuating abnormal DNA methylation induced by PM2.5 in rats. This study may provide a new insight into the physiological function of vitamin B to prevent the health effects induced by PM2.5 .
科研通智能强力驱动
Strongly Powered by AbleSci AI