血脂异常
医学
内科学
荟萃分析
胆固醇
玉米黄质
随机对照试验
阿托伐他汀
叶黄素
内分泌学
科克伦图书馆
胃肠病学
化学
肥胖
生物化学
类胡萝卜素
作者
Fatemeh Ghasemi,Fatemeh Navab,Mohammad Hossein Rouhani,Pegah Amini,Nafiseh Shokri Mashhadi
标识
DOI:10.1016/j.prostaglandins.2022.106691
摘要
The relationship between circulating Lutein and zeaxanthin (L/Z) concentrations, and plasma lipoproteins has been indicated by observational studies. However, the beneficial impact of L/Z administration on dyslipidemia are unclear. This meta-analysis aimed to investigate the effect of oral intake of L/Z on circulating total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), as well as high-density lipoprotein-cholesterol (HDL-C) levels.We electronically assessed all eligible interventional studies through different electronic databases, including PubMed, Scopus, ISI -Web of Science, and Cochrane library until Jun 2021. After identifying the quality of each included randomized controlled trials, they were evaluated by assessing the risk-difference between treatment and control groups by pooling available data on net change of serum LDL-C, HDL-C, and Cholesterol.L/Z supplementation has null effect on circulating levels of TC (WMD: -3.82 95% CI: -13.83, 6.18; I-square: 85.2%), and LDL-C (WMD: -4.54; 95% CI: -11.5, 2.48; I-square: 83.9%). In contrast, L/Z treatment could significantly increase HDL-C levels in older adults (WMD: 4.06; 95% CI: 0.64, 7.48; I-square: 50.7%).L/Z administration could be an effective treatment for improving circulating HDL-C concentration in elderly adults.
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