Most robot manipulators usually operate under different nonlinearities, such as state constraints, time delays, and actuator input saturation faults. This paper proposes an adaptive finite-time fault-tolerant controller for the full-state-constrained robotic manipulator with novel prescribed performance and time-varying delays. Firstly, a novel prescribed performance function consisting of hyperbolic tangent and hyperbolic cotangent functions is constructed to the full-state performance constraints of the robotic manipulator. Such a design can circumvent the demands for accurate initial conditions of the state variables and guarantee the convergence of the state errors in a prescribed time. Then, based on the finite-time principle, a finite-time command filter and a compensation mechanism with fractional-power terms are used to bypass the “explosion of complexity” and further compensate for the filter errors within a finite time. Moreover, a proper Lyapunov–Krasovskii functional is devised within the controller design to compensate for the time-varying delays. And the radial basis function neural networks are used to estimate the other nonlinearities including actuator saturation faults, and external perturbations. Finally, simulation results exhibit that the controller designed in this paper has a faster convergence speed and minor state errors.