生物分子
质谱法
金属
化学
纳米技术
有机体
人类健康
环境化学
计算生物学
材料科学
生物
生物化学
色谱法
有机化学
医学
古生物学
环境卫生
作者
Samuel E. Janisse,Rebeca L. Fernandez,Marie C. Heffern
标识
DOI:10.1016/j.tibs.2023.06.006
摘要
Metal micronutrients are essential for life and exist in a delicate balance to maintain an organism's health. The labile nature of metal-biomolecule interactions clouds the understanding of metal binders and metal-mediated conformational changes that are influential to health and disease. Mass spectrometry (MS)-based methods and technologies have been developed to better understand metal micronutrient dynamics in the intra- and extracellular environment. In this review, we describe the challenges associated with studying labile metals in human biology and highlight MS-based methods for the discovery and study of metal-biomolecule interactions.
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