Antibacterial activity and action mechanism of curcusionol from Carex siderosticta Hance against Ralstonia nicotianae

青枯菌 抗菌活性 烟草疫霉 生物 抗菌剂 传统医学 最小抑制浓度 微生物学 化学 细菌 植物 抗菌剂 抗生素 病菌 医学 遗传学 疫霉菌
作者
Xingyu Ren,Juan Zhou,Ting Liu,Chenquan Zhong,Yong Wang,Yan He,Juntao Feng
出处
期刊:Pest Management Science [Wiley]
卷期号:79 (11): 4607-4616 被引量:1
标识
DOI:10.1002/ps.7661
摘要

Tobacco bacterial wilt is a typical soil-borne disease caused by Ralstonia nicotianae, which causes huge losses in tobacco production every year. The crude extract of Carex siderosticta Hance was shown to have antibacterial activity against R. nicotianae during our search, and the natural antibacterial components were sought after using bioassay-guided fractionation of the compounds.Ethanol extract of Carex siderosticta Hance with the minimum inhibitory concentration (MIC) value of 100 μg/mL against R. nicotianae in vitro. The potential of these compounds as antibactericides against R. nicotianae were assessed. Curcusionol (1), showed the highest antibacterial activity against R. nicotianae with MIC value of 12.5 μg/mL in vitro. In the protective effect tests, the control effect of curcusionol (1) was 92.31 and 72.60%, respectively, after application of 7 and 14 days, at a concentration of 1500 μg/mL, being comparable to that of streptomycin sulfate at a concentration of 500 μg/mL, confirming that curcusionol (1) showed the potential for the development of new antibacterial drugs. RNA-sequencing, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis confirmed that curcusionol mainly destroys R. nicotianae cell membrane structure and affects quorum sensing (QS) to inhibit pathogenic bacteria.This study revealed that the antibacterial activity of Carex siderosticta Hance makes it a botanical bactericide against R. nicotianae, while curcusionol as lead structures for antibacterial development is obvious by its potent antibacterial activity. © 2023 Society of Chemical Industry.
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