Increased cardiovascular morbidity and mortality in patients with resistance to thyroid hormone

The main actions of thyroid hormone are induced through binding of the bioactive hormone T3 to nuclear thyroid hormone receptors (TRs). 1 Brent GA Mechanisms of thyroid hormone action. J Clin Invest. 2012; 122: 3035-3043 Crossref PubMed Scopus (679) Google Scholar There are two receptor types, encoded by the genes THRA and THRB, with differing tissue expressions. TRα1 is primarily expressed in the heart, bone, gastrointestinal tract, skeletal muscle, and brain. TRβ1 is abundantly expressed and is the predominant form in the liver and kidneys, whereas TRβ2 has a more limited expression, including the hypothalamus and pituitary gland. Cardiovascular morbidity and mortality in patients in Wales, UK with resistance to thyroid hormone β (RTHβ): a linked-record cohort studyWe have documented reduced survival and increased cardiovascular morbidity in a cohort of patients with RTHβ for the first time. These outcomes might be driven by lifelong cardiac exposure to thyroid hormone excess; and effective therapies, targeting hormone resistant pathways, could potentially curtail this risk. Full-Text PDF