Identification and quality evaluation of different processed products of Aconitum carmichaelii by ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry and ultra‐high‐performance liquid chromatography‐tandem mass spectrometry

四极飞行时间 串联质谱法 质谱法 色谱法 化学 高效液相色谱法 液相色谱-质谱法
作者
Nina Wei,Dandan Song,Chang Lu,Yong Jiang,Qin Liu,Lunyuan Liu,Xu Liu,Linwei Chen,Zhipeng Chen
出处
期刊:Journal of Separation Science [Wiley]
卷期号:46 (17) 被引量:2
标识
DOI:10.1002/jssc.202300235
摘要

Aconitum carmichaelii is widely used to treat chronic and intractable diseases due to its remarkable curative effect, but it is also a highly toxic herb with severe cardiac and neurotoxicity. It has been combined with honey for thousands of years to reduce toxicity and enhance efficacy, but there has been no study on the chemical constituent changes in the honey-processing so far. In this study, the chemical constituents of A. carmichaelii before and after honey-processing were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. The results showed that a total of 118 compounds were identified, of which six compounds disappeared and five compounds were newly produced after honey-processing, and the cleavage pathway of main components was elucidated. At the same time, 25 compounds were found to have significant effects on different products, among which four compounds with the biggest difference were selected for quantitative analysis by ultra-high-performance liquid chromatography-tandem mass spectrometry. This study not only explained the chemical differences between the different products, but also helped to control the quality of the honey-processed products more effectively, and laid a foundation for further elucidating the mechanism of chemical constituent change during the honey-processing of A. carmichaelii.
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