分解代谢抑制
生物
核糖核酸
核糖开关
生物化学
抄写(语言学)
计算生物学
基因
细胞生物学
非编码RNA
突变体
语言学
哲学
作者
María Soledad Vela Gurovic,Fátima R. Viceconte,Maximiliano Bidegain,Julián Dietrich
标识
DOI:10.1093/jambio/lxac002
摘要
Microbial strategies for biomass deconstruction involve an incredible repertoire of enzymatic, structural, and regulatory proteins. From carbohydrate active enzymes to cellulosomes, bacteria, yeast, and filamentous fungi adapt their functional machinery to grow from alternative carbon sources such as lignocellulose and survive starvation. In that context, microbes must be able to sense, bind, degrade, and utilize lignin, cellulose, and hemicelluloses. Nature has developed specialized protein modules, RNA structures, and regulatory systems operating at a genomic, transcription, and translation level. This review briefly summarizes the main regulatory pathways involved in lignocellulose microbial degradation, including carbon catabolite repression; anti-sigma factors; regulatory RNA elements such as small RNAs, antisense RNA, RNA-binding proteins, and selective RNA processing and stabilization; and transcriptional regulators and unfolded protein response. Interplay with global regulators controlling pH response and nitrogen utilization is also revised.
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