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Efficacy of 1‐kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double‐blind, placebo‐controlled pilot study

溃疡性结肠炎 医学 胃肠病学 内科学 安慰剂 结肠炎 病理 替代医学 疾病
作者
Shuji Ikegami,Masanao Nakamura,Takashi Honda,Takeshi Yamamura,Keiko Maeda,Tsunaki Sawada,Eri Ishikawa,Kenta Yamamoto,Satoshi Furune,Takuya Ishikawa,Kazuhiro Furukawa,Eizaburo Ohno,Masatoshi Ishigami,Fumie Kinoshita,Yoshihiro Kadota,Takumi Tochio,Yoshiharu Shimomura,Yoshiki Hirooka,Hiroki Kawashima
出处
期刊:Alimentary Pharmacology & Therapeutics [Wiley]
卷期号:57 (11): 1249-1257 被引量:14
标识
DOI:10.1111/apt.17387
摘要

Summary Background Ulcerative colitis involves an excessive immune response to intestinal bacteria. Whether administering prebiotic 1‐kestose is effective for active ulcerative colitis remains controversial. Aims This randomised, double‐blind, placebo‐controlled pilot trial investigated the efficacy of 1‐kestose against active ulcerative colitis. Methods Forty patients with mild to moderate active ulcerative colitis were randomly treated with 1‐kestose ( N = 20) or placebo (maltose, N = 20) orally for 8 weeks in addition to the standard treatment. The Lichtiger clinical activity index and Ulcerative Colitis Endoscopic Index of Severity were determined. Faecal samples were analysed to evaluate the gut microbiome and metabolites. Results The clinical activity index at week 8 was significantly lower in the 1‐kestose group than in the placebo group (3.8 ± 2.7 vs. 5.6 ± 2.1, p = 0.026). Clinical remission and response rates were higher in the 1‐kestose group than in the placebo group (remission: 55% vs. 20%, p = 0.048; response: 60% vs. 25%, p = 0.054). The Ulcerative Colitis Endoscopic Index of Severity at week 8 was not significantly different (2.8 ± 1.6 vs. 3.5 ± 1.6, p = 0.145). Faecal analysis showed significantly reduced alpha‐diversity in the 1‐kestose group, with a decreased relative abundance of several bacteria, including Ruminococcus gnavus group . The short‐chain fatty acid levels were not significantly different between the groups. The incidence of adverse events was comparable between the groups. Discussion Oral 1‐kestose is well tolerated and provides clinical improvement for patients with mild to moderate ulcerative colitis through modulation of the gut microbiome.
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