Efficacy of 1‐kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double‐blind, placebo‐controlled pilot study

溃疡性结肠炎 医学 胃肠病学 内科学 安慰剂 结肠炎 病理 替代医学 疾病
作者
Shuji Ikegami,Masanao Nakamura,Takashi Honda,Takeshi Yamamura,Keiko Maeda,Tsunaki Sawada,Eri Ishikawa,Kenta Yamamoto,Satoshi Furune,Takuya Ishikawa,Kazuhiro Furukawa,Eizaburo Ohno,Masatoshi Ishigami,Fumie Kinoshita,Yoshihiro Kadota,Takumi Tochio,Yoshiharu Shimomura,Yoshiki Hirooka,Hiroki Kawashima
出处
期刊:Alimentary Pharmacology & Therapeutics [Wiley]
卷期号:57 (11): 1249-1257 被引量:14
标识
DOI:10.1111/apt.17387
摘要

Summary Background Ulcerative colitis involves an excessive immune response to intestinal bacteria. Whether administering prebiotic 1‐kestose is effective for active ulcerative colitis remains controversial. Aims This randomised, double‐blind, placebo‐controlled pilot trial investigated the efficacy of 1‐kestose against active ulcerative colitis. Methods Forty patients with mild to moderate active ulcerative colitis were randomly treated with 1‐kestose ( N = 20) or placebo (maltose, N = 20) orally for 8 weeks in addition to the standard treatment. The Lichtiger clinical activity index and Ulcerative Colitis Endoscopic Index of Severity were determined. Faecal samples were analysed to evaluate the gut microbiome and metabolites. Results The clinical activity index at week 8 was significantly lower in the 1‐kestose group than in the placebo group (3.8 ± 2.7 vs. 5.6 ± 2.1, p = 0.026). Clinical remission and response rates were higher in the 1‐kestose group than in the placebo group (remission: 55% vs. 20%, p = 0.048; response: 60% vs. 25%, p = 0.054). The Ulcerative Colitis Endoscopic Index of Severity at week 8 was not significantly different (2.8 ± 1.6 vs. 3.5 ± 1.6, p = 0.145). Faecal analysis showed significantly reduced alpha‐diversity in the 1‐kestose group, with a decreased relative abundance of several bacteria, including Ruminococcus gnavus group . The short‐chain fatty acid levels were not significantly different between the groups. The incidence of adverse events was comparable between the groups. Discussion Oral 1‐kestose is well tolerated and provides clinical improvement for patients with mild to moderate ulcerative colitis through modulation of the gut microbiome.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
z69823完成签到,获得积分10
1秒前
1秒前
1秒前
1秒前
小灰灰发布了新的文献求助10
1秒前
vvv发布了新的文献求助10
2秒前
liuyx完成签到 ,获得积分10
2秒前
脑洞疼应助lizheng采纳,获得10
2秒前
2秒前
啊棕发布了新的文献求助10
3秒前
彭于晏应助为学日益采纳,获得10
3秒前
4秒前
wjx发布了新的文献求助10
4秒前
lk发布了新的文献求助10
4秒前
4秒前
4秒前
英姑应助沉默的宛筠采纳,获得10
4秒前
5秒前
从若关注了科研通微信公众号
5秒前
英语完成签到,获得积分10
5秒前
yulee完成签到,获得积分10
5秒前
6秒前
慕青应助aa采纳,获得30
7秒前
vvan发布了新的文献求助10
7秒前
田様应助落后钢铁侠采纳,获得10
7秒前
7秒前
SJTU_Rainking发布了新的文献求助10
7秒前
7秒前
8秒前
Srui完成签到,获得积分10
8秒前
8秒前
西门子云发布了新的文献求助10
8秒前
8秒前
9秒前
豆子完成签到,获得积分10
9秒前
9秒前
9秒前
大模型应助李山鬼采纳,获得10
9秒前
ZZ发布了新的文献求助10
10秒前
wyl发布了新的文献求助10
10秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974463
求助须知:如何正确求助?哪些是违规求助? 3518823
关于积分的说明 11196212
捐赠科研通 3255008
什么是DOI,文献DOI怎么找? 1797655
邀请新用户注册赠送积分活动 877052
科研通“疑难数据库(出版商)”最低求助积分说明 806130