肝细胞癌
靶向治疗
血小板
癌症研究
医学
纳米技术
内科学
材料科学
癌症
作者
Yuesong Wu,Qingze Fan,Jiahan Zhou,Haiyang Hu,Zuyue Liao,Xiaoqin Tang,Mengyao Xu,Shuo Yang,Jia Lai,Shengli Wan,Jianming Wu
标识
DOI:10.1016/j.colsurfb.2024.113973
摘要
Curcumin (CUR) is a promising natural product for hepatocellular carcinoma (HCC) therapy. However, its clinical application has been limited by some issues such as rapid clearance and inadequate tumor accumulation. To address these drawbacks, we developed platelet membrane-coated CUR-loaded PLGA nanoparticles (PCPNPs). In this work, due to the bioinspired strategy, the PCPNPs exhibited immune evasion, prolonged circulation, and improved accumulation at tumor sites compared to the traditional CUR formulation. The superior tumor targeting of PCPNPs was likely due to the interactions between platelet P-selectin and tumoral CD44. Furthermore, both in vitro and in vivo assays revealed that the PCPNPs showed outstanding anticancer efficacy without obvious toxicity. Therefore, PCPNPs represent a biosafe and promising anti-tumor strategy, overcoming the limitations associated with CUR. These findings not only contribute to the advancement of natural compound nano-formulation but also open new avenues for targeted cancer treatment.
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