From bile acids to melancholia

In this issue of Neuron, Li, Zhang, et al. 1 Li X.-Y. Zhang S.-Y. Hong Y.-Z. Chen Z.-G. Long Y. Zhao J.-J. Tang S.-S. Wang H. Hong H. TGR5-mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Triple Circuit 1 Regulates Depressive-like Behavior in Male Mice. Neuron. 2024; 112: 1795-1814.e10https://doi.org/10.1016/j.neuron.2024.02.019 Abstract Full Text Full Text PDF Scopus (0) Google Scholar find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression. In this issue of Neuron, Li, Zhang, et al. 1 Li X.-Y. Zhang S.-Y. Hong Y.-Z. Chen Z.-G. Long Y. Zhao J.-J. Tang S.-S. Wang H. Hong H. TGR5-mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Triple Circuit 1 Regulates Depressive-like Behavior in Male Mice. Neuron. 2024; 112: 1795-1814.e10https://doi.org/10.1016/j.neuron.2024.02.019 Abstract Full Text Full Text PDF Scopus (0) Google Scholar find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression. TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male miceLi et al.NeuronMarch 21, 2024In BriefLi et al. uncover that the increase in bile acid TGR5 membrane-type receptor in the lateral hypothalamic area improves depressive-like behavior and reveal a potential therapeutic strategy, activating TGR5 by supplementing bile acids for depression. Full-Text PDF