克
环胺
比例(比率)
化学
生物
生物化学
遗传学
物理
细菌
刺猬
量子力学
基因
作者
Hou Wen-long,Heshan Lin,Yufan Wu,Chuang Li,Jiajun Chen,Xiaoyu Liu,Yong Qin
标识
DOI:10.1038/s41467-024-49748-2
摘要
Veratramine and cyclopamine, two of the most representative members of the isosteroidal alkaloids, are valuable molecules in agricultural and medicinal chemistry. While plant extraction of these compounds suffers from uncertain supply, efficient chemical synthesis approaches are in high demand. Here, we present concise, divergent, and scalable syntheses of veratramine and cyclopamine with 11% and 6.2% overall yield, respectively, from inexpensive dehydro-epi-androsterone. Our synthesis readily provides gram quantities of both target natural products by utilizing a biomimetic rearrangement to form the C-nor-D-homo steroid core and a stereoselective reductive coupling/(bis-)cyclization sequence to establish the (E)/F-ring moiety.
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