葡萄糖氧化酶
纳米反应器
材料科学
过氧化氢
伤口愈合
硫酸软骨素
纳米技术
化学
药理学
医学
生物化学
外科
生物传感器
糖胺聚糖
纳米颗粒
作者
Guangli Xiang,Bingjie Wang,Wenshang Zhang,Yu Dong,Jiaojiao Tao,Aijia Zhang,Rui Chen,Tianze Jiang,Xia Zhao
标识
DOI:10.1016/j.actbio.2024.05.015
摘要
Diabetic wound healing is a great clinical challenge due to the microenvironment of hyperglycemia and high pH value, bacterial infection and persistent inflammation. Here, we develop a cascade nanoreactor hydrogel (Arg@Zn-MOF-GOx Gel, AZG-Gel) with arginine (Arg) loaded Zinc metal organic framework (Zn-MOF) and glucose oxidase (GOx) based on chondroitin sulfate (CS) and Pluronic (F127) to accelerate diabetic infected wound healing. GOx in AZG-Gel was triggered by hyperglycemic environment to reduce local glucose and pH, and simultaneously produced hydrogen peroxide (H
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