医学
荟萃分析
甲状腺
科克伦图书馆
甲状腺过氧化物酶
内科学
优势比
促甲状腺激素
甲状腺功能
激素
内分泌学
三碘甲状腺素
置信区间
甲状腺球蛋白
作者
Seung Min Chung,Min Cheol Chang
出处
期刊:Reviews on environmental health
[De Gruyter]
日期:2023-12-25
标识
DOI:10.1515/reveh-2023-0122
摘要
Abstract Introduction This meta-analysis aimed to analyze the effect of cadmium (Cd) exposure on thyroid hormone disruption. Content Databases including PubMed, Embase, Cochrane Library, and Scopus were searched for studies published up to December 14, 2022. Studies evaluating the association between Cd exposure (blood Cd [BCd] or urine Cd [UCd]) and thyroid function (thyroid-stimulating hormone [TSH], free thyroxine [FT4], total triiodothyronine [TT3]) or thyroid autoimmunity (thyroglobulin antibody [TgAb] or thyroperoxidase Ab [TPOAb]) were included. Summary and Outlook This systematic review included 12 cross-sectional studies. Cd exposure showed a neutral association with TSH (pooled correlation=0.016, 95 % confidence interval [CI]=−0.013 to 0.045, p=0.277), FT4 (pooled correlation=0.028, 95 % CI=−0.005 to 0.061, p=0.098), and thyroid autoimmunity (pooled odds ratio=1.143, 95 % CI=0.820–1.591, p=0.430). However, Cd exposure showed a positive association with TT3 (pooled correlation=0.065, 95 % CI=0.050–0.080, p<0.001), which was consistent with the BCd and UCd subgroup analyses (pooled correlation=0.053 and 0.081, respectively, both p<0.001). Cd exposure was not associated with TSH, FT4, or thyroid autoimmunity but tended to increase with TT3.
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