神经病理性疼痛
神经科学
激酶
微管
医学
丝氨酸苏氨酸激酶
药理学
化学
生物
细胞生物学
生物化学
蛋白激酶A
作者
Yaoqin Shi,Zhi‐Hong Sun,Zhezhe Wang,Chunyu Su,Wei Zhang,Linyao Yu,Yang Xu,Yonglin Gao,Hongbo Wang,Jingwei Tian,Chunmei Li
摘要
Neuropathic pain affects millions of patients, but there are currently few viable therapeutic options available. Microtubule affinity-regulating kinases (MARKs) regulate the dynamics of microtubules and participate in synaptic remodelling. It is unclear whether these changes are involved in the central sensitization of neuropathic pain. This study examined the role of MARK1 or MARK2 in regulating neurosynaptic plasticity induced by neuropathic pain.
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