Red ginseng ameliorates lipotoxicity-induced renal fibrosis in hyperuricemia mice

脂毒性 高尿酸血症 人参 医学 纤维化 传统医学 生药学 药理学 内科学 内分泌学 尿酸 生物 病理 生物活性 糖尿病 生物化学 体外 胰岛素抵抗 替代医学
作者
Yingling Zhang,Si-Min Chen,Yijie Song,Md Ariful Islam,Pei-Li Rao,Meng-Jie Zhu,Wen Gu,Xu Yu,Hong‐Xi Xu
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:327: 118014-118014 被引量:2
标识
DOI:10.1016/j.jep.2024.118014
摘要

Chronic kidney disease can be caused by numerous diseases including obesity and hyperuricemia (HUA). Obesity may exacerbate the renal injury caused by HUA. Red ginseng, a steamed products of Panax ginseng Meyer root, is known for its remarkable efficacy in improving metabolic syndrome, such as maintaining lipid metabolic balance. However, the role of red ginseng on hyperuricemia-induced renal injury in obese cases remains unclear. This study aimed to investigate the action of red ginseng extract (RGE) on lipotoxicity-induced renal injury in HUA mice. A high-fat diet (HFD)-induced obesity model was employed to initially investigate the effects of RGE on body weight, TC, OGTT, renal lipid droplets, and renal function indices such as uric acid, creatinine, and urea nitrogen. Renal structural improvement was demonstrated by H&E staining. Subsequently, an animal model combining obesity and HUA was established to further study the impact of RGE on OAT1 and ACC1 expression levels. The mechanisms underlying renal injury regulation by RGE were postulated on the basis of RNA sequencing, which was verified by immunohistochemical (including F4/80, Ki67, TGF-β1, α-SMA, and E-cadherin), Masson, and Sirius red staining. RGE modulated HFD-induced weight gain, glucose metabolism, and abnormalities of uric acid, urea nitrogen, and creatinine. RGE alleviated the more severe renal histopathological changes induced by obesity combined with HUA, with down-regulated the protein levels of ACC1, F4/80, Ki67, TGF-β1, and α-SMA, and up-regulated OAT1 and E-cadherin. RGE has ameliorative effects on chronic kidney disease caused by obesity combined with HUA by maintaining lipid balance and reducing renal inflammation and fibrosis.
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