波姆裂殖酵母
细胞周期
合成生物学
细胞生物学
酵母
背景(考古学)
细胞周期进展
生物
裂殖酵母
计算生物学
细胞
细胞生长
酿酒酵母
遗传学
古生物学
作者
Akanksha Jain,Pei-Yun Jenny Wu,Damien Coudreuse
出处
期刊:Methods in molecular biology
日期:2024-01-01
卷期号:: 89-105
标识
DOI:10.1007/978-1-0716-3557-5_5
摘要
Cell cycle control is a central aspect of the biology of proliferating eukaryotic cells. However, progression through the cell cycle relies on a highly complex network, making it difficult to unravel the core design principles underlying the mechanisms that sustain cell proliferation and the ways in which they interact with other cellular pathways. In this context, the use of a synthetic approach to simplify the cell cycle network in unicellular genetic models such as fission yeast has opened the door to studying the biology of proliferating cells from unique perspectives. Here, we provide a series of methods based on a minimal cell cycle module in the fission yeast Schizosaccharomyces pombe that allows for an unprecedented artificial control of cell cycle events, enabling the rewiring and remodeling of cell cycle progression.
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