微气泡
超声波
药物输送
体内
细胞内
分子成像
纳米技术
材料科学
生物医学工程
化学
医学
放射科
生物化学
生物技术
生物
作者
Rajkumar Sahoo,Ankan Kumar Sarkar,Haydar Ali,Nikhil R. Jana
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-02-23
卷期号:7 (3): 1852-1861
被引量:1
标识
DOI:10.1021/acsabm.3c01245
摘要
Ultrasound-based therapy is appealing as it can be used via a wireless approach at remote parts of the body including the brain. Microbubbles are commonly used in such therapy due to their highly sound-responsive property. However, the larger size of microbubbles limits selective targeting in vitro/in vivo. Here, we report the design of nanodroplets of 70–130 nm in size that can be easily converted to microbubbles via ultrasound exposure. The advantage of this approach is that smaller nanodroplets can be used for cell/subcellular targeting, and next, they can be used for therapy by converting to microbubbles. More specifically, folate/dopamine-terminated perfluorohexane nanodroplets are designed that are loaded with a molecular drug. These nanodroplets are used for selective cell targeting, followed by ultrasound-induced microbubble conversion that is associated with drug release and intracellular reactive oxygen species generation. This approach has been used for selective cell therapy applications. The designed nanodroplet and approach can be used for the enhanced therapeutic performance of existing drugs.
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