Ultrasound-Responsive Nanodroplet-Based Targeted Therapy via Conversion to Microbubbles

微气泡 超声波 药物输送 体内 细胞内 分子成像 纳米技术 材料科学 生物医学工程 化学 医学 放射科 生物化学 生物技术 生物
作者
Rajkumar Sahoo,Ankan Kumar Sarkar,Haydar Ali,Nikhil R. Jana
出处
期刊:ACS applied bio materials [American Chemical Society]
卷期号:7 (3): 1852-1861 被引量:1
标识
DOI:10.1021/acsabm.3c01245
摘要

Ultrasound-based therapy is appealing as it can be used via a wireless approach at remote parts of the body including the brain. Microbubbles are commonly used in such therapy due to their highly sound-responsive property. However, the larger size of microbubbles limits selective targeting in vitro/in vivo. Here, we report the design of nanodroplets of 70–130 nm in size that can be easily converted to microbubbles via ultrasound exposure. The advantage of this approach is that smaller nanodroplets can be used for cell/subcellular targeting, and next, they can be used for therapy by converting to microbubbles. More specifically, folate/dopamine-terminated perfluorohexane nanodroplets are designed that are loaded with a molecular drug. These nanodroplets are used for selective cell targeting, followed by ultrasound-induced microbubble conversion that is associated with drug release and intracellular reactive oxygen species generation. This approach has been used for selective cell therapy applications. The designed nanodroplet and approach can be used for the enhanced therapeutic performance of existing drugs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SciGPT应助科研通管家采纳,获得10
1秒前
1秒前
1秒前
田様应助scienceljk采纳,获得10
1秒前
lyj334发布了新的文献求助10
1秒前
wo发布了新的文献求助50
2秒前
LL完成签到,获得积分10
2秒前
aaa完成签到,获得积分10
3秒前
4秒前
yzshiny应助文件撤销了驳回
4秒前
hauru发布了新的文献求助30
4秒前
王俊发布了新的文献求助10
4秒前
卢鑫宇发布了新的文献求助10
5秒前
6秒前
7秒前
7秒前
明明发布了新的文献求助10
7秒前
8秒前
Lucas应助GuangChe采纳,获得10
8秒前
朴实的宝莹完成签到 ,获得积分10
9秒前
9秒前
传奇3应助fer采纳,获得10
9秒前
9秒前
调研昵称发布了新的文献求助10
10秒前
苍苍完成签到,获得积分10
10秒前
烟花应助拼搏老鼠采纳,获得30
10秒前
lyj334完成签到,获得积分10
11秒前
Anonymous发布了新的文献求助10
11秒前
威武的晓丝完成签到,获得积分10
12秒前
FashionBoy应助钱小二采纳,获得10
12秒前
自行设置发布了新的文献求助10
13秒前
HUSH994完成签到,获得积分10
13秒前
13秒前
可耐的Gamma完成签到,获得积分10
14秒前
情怀应助王俊采纳,获得10
15秒前
15秒前
16秒前
16秒前
爆米花应助Han采纳,获得10
17秒前
17秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
Shining Light on the Dark Side of Personality 400
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3308114
求助须知:如何正确求助?哪些是违规求助? 2941617
关于积分的说明 8504720
捐赠科研通 2616297
什么是DOI,文献DOI怎么找? 1429556
科研通“疑难数据库(出版商)”最低求助积分说明 663807
邀请新用户注册赠送积分活动 648748