Free Water MR Imaging of White Matter Microstructural Changes is a Sensitive Marker of Amyloid Positivity in Alzheimer's Disease

磁共振弥散成像 白质 核医学 接收机工作特性 医学 部分各向异性 曲线下面积 内科学 曼惠特尼U检验 磁共振成像 放射科
作者
Xuan Sun,Cui Zhao,Siyu Chen,Yan Chang,Yuliang Han,Ke Li,Hong‐Mei Sun,Zhenfu Wang,Ying Liang,Jianjun Jia
出处
期刊:Journal of Magnetic Resonance Imaging [Wiley]
卷期号:60 (4): 1458-1469 被引量:4
标识
DOI:10.1002/jmri.29189
摘要

Background Extracellular free water (FW) resulting from white matter degeneration limits the sensitivity of diffusion tensor imaging (DTI) in predicting Alzheimer's disease (AD). Purpose To evaluate the sensitivity of FW‐DTI in detecting white matter microstructural changes in AD. To validate the effectiveness of FW‐DTI indices to predict amyloid‐beta (Aβ) positivity in mild cognitive impairment (MCI) subtypes. Study Type Retrospective. Population Thirty‐eight Aβ‐negative cognitively healthy (CH) controls (68.74 ± 8.28 years old, 55% female), 15 Aβ‐negative MCI patients (MCI‐n) (68.87 ± 8.83 years old, 60% female), 29 Aβ‐positive MCI patients (MCI‐p) (73.03 ± 7.05 years old, 52% female), and 29 Aβ‐positive AD patients (72.93 ± 9.11 years old, 55% female). Field Strength/Sequence 3.0T; DTI, T 1 ‐weighted, T 2 ‐weighted, T 2 star‐weighted angiography, and Aβ PET ( 18 F‐florbetaben or 11 C‐PIB). Assessment FW‐corrected and standard diffusion indices were analyzed using trace‐based spatial statistics. Area under the curve (AUC) in distinguishing MCI subtypes were compared using support vector machine (SVM). Statistical Tests Chi‐squared test, one‐way analysis of covariance, general linear regression analyses, nonparametric permutation tests, partial Pearson's correlation, receiver operating characteristic curve analysis, and linear SVM. A P value <0.05 was considered statistically significant. Results Compared with CH/MCI‐n/MCI‐p, AD showed significant change in tissue compartment indices of FW‐DTI. No difference was found in the FW index among pair‐wise group comparisons (the minimum FWE‐corrected P = 0.114). There was a significant association between FW‐DTI indices and memory and visuospatial function. The SVM classifier with tissue radial diffusivity as an input feature had the best classification performance of MCI subtypes (AUC = 0.91), and the classifying accuracy of FW‐DTI was all over 89.89%. Data Conclusion FW‐DTI indices prove to be potential biomarkers of AD. The classification of MCI subtypes based on SVM and FW‐DTI indices has good accuracy and could help early diagnosis. Evidence Level 4 Technical Efficacy Stage 2
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
树林红了完成签到,获得积分10
刚刚
聪慧的小伙完成签到,获得积分10
刚刚
刚刚
刚刚
搜集达人应助嗷嗷采纳,获得10
刚刚
科研通AI5应助生动的翠容采纳,获得10
刚刚
万能图书馆应助背后如雪采纳,获得10
1秒前
轻松板栗发布了新的文献求助10
1秒前
小叶完成签到,获得积分10
1秒前
鲸鱼发布了新的文献求助10
1秒前
OrangeBlueHeart完成签到,获得积分10
2秒前
次我完成签到,获得积分10
2秒前
2秒前
kirakira完成签到,获得积分10
3秒前
111完成签到,获得积分10
3秒前
3秒前
吴某完成签到,获得积分20
4秒前
慕青应助皮蛋solo粥采纳,获得30
4秒前
发论文完成签到 ,获得积分10
4秒前
南松发布了新的文献求助10
4秒前
4秒前
Rubby应助dfsdf采纳,获得10
4秒前
小明应助dfsdf采纳,获得10
4秒前
李健的小迷弟应助PaoPao采纳,获得10
5秒前
5秒前
CipherSage应助wzl采纳,获得10
5秒前
小巧风华发布了新的文献求助10
5秒前
反方向的钟完成签到,获得积分10
6秒前
6秒前
6秒前
香妃发布了新的文献求助10
7秒前
lxyy应助迷你的依凝采纳,获得10
7秒前
8秒前
8秒前
fazat完成签到,获得积分10
8秒前
量子星尘发布了新的文献求助10
9秒前
9秒前
糊涂涂发布了新的文献求助30
10秒前
10秒前
10秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
计划经济时代的工厂管理与工人状况(1949-1966)——以郑州市国营工厂为例 500
INQUIRY-BASED PEDAGOGY TO SUPPORT STEM LEARNING AND 21ST CENTURY SKILLS: PREPARING NEW TEACHERS TO IMPLEMENT PROJECT AND PROBLEM-BASED LEARNING 500
The Pedagogical Leadership in the Early Years (PLEY) Quality Rating Scale 410
Stackable Smart Footwear Rack Using Infrared Sensor 300
Modern Britain, 1750 to the Present (第2版) 300
Writing to the Rhythm of Labor Cultural Politics of the Chinese Revolution, 1942–1976 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4603484
求助须知:如何正确求助?哪些是违规求助? 4012177
关于积分的说明 12422449
捐赠科研通 3692673
什么是DOI,文献DOI怎么找? 2035749
邀请新用户注册赠送积分活动 1068916
科研通“疑难数据库(出版商)”最低求助积分说明 953403