生化工程
代谢工程
发酵
背景(考古学)
生物技术
生物燃料
人口
生物量(生态学)
化石燃料
工具箱
自养
环境科学
化学
生物
工程类
废物管理
细菌
生态学
食品科学
生物化学
机械工程
古生物学
遗传学
人口学
社会学
酶
作者
Sai Wan,Mingchi Lai,Xinyu Gao,Mingxin Zhou,Song Yang,Qiang Li,Fuli Li,Lin Xia,Yang Tan
标识
DOI:10.1016/j.synbio.2023.12.001
摘要
Excessive mining and utilization fossil fuels has led to drastic environmental consequences, which will contribute to global warming and cause further climate change with severe consequences for the human population. The magnitude of these challenges requires several approaches to develop sustainable alternatives for chemicals and fuels production. In this context, biological processes, mainly microbial fermentation, have gained particular interest. For example, autotrophic gas-fermenting acetogenic bacteria are capable of converting CO, CO2 and H2 into biomass and multiple metabolites through Wood-Ljungdahl pathway, which can be exploited for large-scale fermentation processes to sustainably produce bulk biochemicals and biofuels (e.g. acetate and ethanol) from syngas. Clostridium autoethanogenum is one representative of these chemoautotrophic bacteria and considered as the model for the gas fermentation. Recently, the development of synthetic biology toolbox for this strain has enabled us to study and genetically improve their metabolic capability in gas fermentation. In this review, we will summarize the recent progress involved in the understanding of physiological mechanism and strain engineering for C. autoethanogenum, and provide our perspectives on the future development about the basic biology and engineering biology of this strain.
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