Advances in Transition-Metal-Catalyzed Keto Carbonyl-Directed C—H Bond Functionalization Reactions

In the past two decades, transition-metal-catalyzed keto carbonyl-directed C-H bond activation has evloved as a powerful and convenient tool for the construction of C-C and C-X (X＝N, F, O) bonds at the unconventional reaction sites of ketones.Among them, keto carbonyl-directed C-H bond activation reactions catalyzed by noble metals, involving ruthenium, rhodium, palladium and iridium, have been widely explored, whilst inexpensive 3d metals, such as manganese, iron and cobalt, have gradually emerged as hotspot catalysts in keto carbonyl-directed C-H activation reactions recently.In this review, advances on transition-metal-catalyzed keto carbonyl-directed C-H bond functionalization reactions from 2014 to 2021 are summarized, which are devided by reaction categories such as alkylation, alkenylation, amidation, arylation, cyclization, and so on.