三氯卡班
三氯生
嗅球
嗅觉
嗅觉系统
化学
细胞生物学
嗅上皮
气味
神经科学
生物
中枢神经系统
医学
病理
作者
Lin Huang,Weixia Zhang,Difei Tong,Lingzheng Lu,Weicheng Zhou,Dandan Tian,Guangxu Liu,Wei Shi
出处
期刊:Water Research
[Elsevier]
日期:2023-02-12
卷期号:233: 119736-119736
被引量:10
标识
DOI:10.1016/j.watres.2023.119736
摘要
Recently, increased production and consumption of disinfectants such as triclosan (TCS) and triclocarban (TCC) have led to massive pollution of the environment, which draws global concern over the potential risk to aquatic organisms. However, the olfactory toxicity of disinfectants in fish remains elusive to date. In the present study, the impact of TCS and TCC on the olfactory capacity of goldfish was assessed by neurophysiological and behavioral approaches. As shown by the reduced distribution shifts toward amino acid stimuli and hampered electro-olfactogram responses, our results demonstrated that TCS/TCC treatment would cause deterioration of the olfactory ability of goldfish. Our further analysis found that TCS/TCC exposure suppressed the expression of olfactory G protein-coupled receptors in the olfactory epithelium, restricted the transformation of odorant stimulation into electrical responses by disturbing the cAMP signaling pathway and ion transportation, and induced apoptosis and inflammation in the olfactory bulb. In conclusion, our results demonstrated that an environmentally realistic level of TCS/TCC would weaken the olfactory capacity of goldfish by constraining odorant recognition efficiency, disrupting olfactory signal generation and transduction, and disturbing olfactory information processing.
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