PI3K/AKT/mTOR通路
蛋白激酶B
血小板
细胞生物学
信号转导
血小板活化
磷脂酰肌醇
细胞内
疾病
生物
神经科学
癌症研究
化学
医学
免疫学
内科学
作者
Mohammad Rafi Khezri,Ayda Esmaeili,Morteza Ghasemnejad‐Berenji
摘要
In recent years, the association between the activity of platelets and risk of Alzheimer's disease (AD) risk has been noticed in numerous studies. However, there in no investigations on the role of specific intracellular pathways to explain this connection. The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is one of the main regulators of cell survival which regulates cellular responses to environmental changes. This pathway also regulates the activity of platelets, and its aberrant activity has been linked to platelet dysfunction in different pathologies. On the other hand, the PI3K/AKT pathway regulates amyloid-β (Aβ) production through regulation of amyloid-β protein precursor (AβPP), BACE-1, ADAMs, and γ-secretase. In addition, alterations in the activity of all of these factors in platelets has been shown in AD-related pathologies. Therefore, this paper aims to introduce the PI3K/AKT pathway as a molecular inducer of platelet dysfunction during aging and AD progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI