抗坏血酸
微分脉冲伏安法
检出限
生物传感器
胶体金
电化学气体传感器
循环伏安法
纳米复合材料
材料科学
纳米颗粒
核化学
二硫化钼
电化学
化学
色谱法
电极
纳米技术
物理化学
食品科学
冶金
作者
Deepshikha Yadav,Shilpi Verma,Jyoti Choudhary,Harleen Kaur,Pratibha Tiwari,Sandeep Kumar Singh,Pallavi Kushwaha,Premshankar K. Dubey,Pranjal Chandra,Surinder P. Singh
标识
DOI:10.1002/elan.202200286
摘要
Abstract Folic acid (FA) deficiency is associated with several clinical conditions such as megaloblastic anemia, neuropsychiatric, and pregnancy‐related syndromes, this makes FA an important metabolite to be monitored. We have fabricated an electrochemical biosensor based on gold nanoparticles decorated molybdenum disulfide nanosheets (AuNPs−MoS 2 NSs) nanocomposite as a transducer matrix for specific and rapid electrochemical detection of FA. Differential pulse voltammetry (DPV) studies displayed a rapid analytical response of the fabricated AuNPs−MoS 2 NSs/GCE sensor probe towards FA in a wide concentration range of 0.001–100 μM with a very low detection limit of 0.72±0.03 nM. The selectivity of the fabricated sensor probe has been examined in the presence of interferents such as dopamine, uric acid, ascorbic acid, glucose, and urea. The clinical potential of the fabricated biosensor was established by monitoring FA in human serum samples. The developed AuNPs−MoS 2 NSs/GCE sensor probe showed high reproducibility and stability, indicating its promise for FA detection in clinical settings.
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